Muffet Bane is the alpha Spiderling Invader of Crux Prime. It is considerably more powerful offensively and defensively than the already difficult Dark Spiderling Invader. Muffet Bane looks very similar to the regular Dark Spiderling Invader, but there are enough differences to tell them apart from a distance (i.e. brighter glow). It is an uncommon Named Enemy to sight, let alone fight.
The name is a reference to "Little Miss Muffet", a nursery rhyme where Muffet is scared away by a spider.